{"id":66,"date":"2010-03-16T17:10:57","date_gmt":"2010-03-16T08:10:57","guid":{"rendered":"https:\/\/saitama-med-allergy.com\/?p=66"},"modified":"2023-03-03T17:11:19","modified_gmt":"2023-03-03T08:11:19","slug":"%e7%b1%b3%e5%9b%bd%e3%82%a2%e3%83%ac%e3%83%ab%e3%82%ae%e3%83%bc%e5%ad%a6%e4%bc%9a%e3%81%ae%e3%81%94%e5%a0%b1%e5%91%8a","status":"publish","type":"post","link":"https:\/\/saitama-med-allergy.com\/?p=66","title":{"rendered":"\u7c73\u56fd\u30a2\u30ec\u30eb\u30ae\u30fc\u5b66\u4f1a\u306e\u3054\u5831\u544a"},"content":{"rendered":"<p><span>\u30002010\u5e74\u5ea6\u306e\u7c73\u56fd\u30a2\u30ec\u30eb\u30ae\u30fc\u5b66\u4f1a\u8b70(American Academy of Allergy, Asthma &amp; Immunology, AAAAI)\u304c2\u670826\u65e5\u304b\u30893\u67082\u65e5\u307e\u3067\u3001\u30eb\u30a4\u30b8\u30a2\u30ca\u5dde\u30cb\u30e5\u30fc\u30aa\u30ea\u30f3\u30ba\u3067\u958b\u50ac\u3055\u308c\u307e\u3057\u305f\u3002\u5f53\u30bb\u30f3\u30bf\u30fc\u304b\u3089\u306f\u7b46\u8005\u304c\u30a2\u30b8\u30a2\u592a\u5e73\u6d0b\u5730\u533a\u7d44\u7e54\u59d4\u54e1\u4f1a\u51fa\u5e2d\u306e\u305f\u3081\u3001\u307e\u305f\u5185\u79d1\u7cfb\u82e5\u624b\u30b9\u30bf\u30c3\u30d5\u304c\uff13\u3064\u306e\u767a\u8868\u6f14\u984c\u3092\u3072\u3063\u3055\u3052\u3066\u51fa\u5e2d\u3057\u3066\u304d\u307e\u3057\u305f\u3002<\/span><br \/>\n<span>\u3000\u30cf\u30ea\u30b1\u30fc\u30f3\u306e\u731b\u5a01\u306b\u5d29\u58ca\u5bf8\u524d\u306b\u9665\u3063\u305f\u540c\u5e02\u3067\u3059\u304c\u5fa9\u8208\u306f\u3081\u3056\u307e\u3057\u304f\u3001\u30b8\u30e3\u30ba\u767a\u7965\u306e\u5357\u90e8\u306e\u8857\u3068\u3057\u3066\u306e\u6d3b\u6c17\u306b\u6e80\u3061\u6e80\u3061\u3066\u3044\u307e\u3057\u305f\u3002\u304a\u308a\u3057\u3082\u30d0\u30f3\u30af\u30fc\u30d0\u30fc\u4e94\u8f2a\u3067\u7c73\u56fd\u30a2\u30a4\u30b9\u30db\u30c3\u30b1\u30fc\u30c1\u30fc\u30e0\u304c\u6c7a\u52dd\u307e\u3067\u9032\u3093\u3060\u6642\u671f\u3067\u3082\u3042\u308a\uff08\u30ab\u30ca\u30c0\u306e\u5929\u624d\u5150\u30b7\u30c9\u30fb\u30af\u30ed\u30ba\u30d3\u30a4\u306b\u91d1\u306e\u5922\u306f\u7d76\u305f\u308c\u307e\u3057\u305f\u304c\uff09\u3001\u7c73\u56fd\u306e\u5b66\u554f\u4ef2\u9593\u305f\u3061\u3082\u76f8\u5f53\u305d\u306e\u8a71\u984c\u306b\u3044\u308c\u3053\u3093\u3067\u3044\u307e\u3057\u305f\u3002<\/span><br \/>\n<span>\u3000AAAAI\u306b\u306f\u7b46\u8005\u306f1990\u5e74\u304b\u3089\u53c2\u52a0\u3092\u7d9a\u3051\u3066\u3044\u307e\u3059\u3002AAAAI\u306e\u5927\u304d\u306a\u7279\u8272\u306f\u5358\u306b\u5927\u898f\u6a21\u306a\u3060\u3051\u3067\u306a\u304f\u3001\u300c\u5e741\u56de\u3053\u3063\u304d\u308a\u300d\u306e\u3053\u306e\u96c6\u4f1a\u3067\u3001\u81e8\u5e8a\u7814\u4fee\u7684\u30d7\u30ed\u30b0\u30e9\u30e0\u304b\u3089\u81e8\u5e8a\u514d\u75ab\u30fb\u30a2\u30ec\u30eb\u30ae\u30fc\u5b66\u306b\u95a2\u308f\u308b\u6700\u65b0\u306e\u77e5\u898b\u306b\u3044\u305f\u308b\u307e\u3067\u30011\u5e74\u306eUPDATE\u304c\u307b\u307c\u7db2\u7f85\u3055\u308c\u308b\u3053\u3068\u306b\u3042\u308a\u307e\u3059\u3002\u305d\u306e\u30d9\u30fc\u30b9\u306b\u306f\u9023\u65e5\u958b\u50ac\u3055\u308c\u308b\u30d7\u30ec\u30ca\u30ea\u30fc\uff08\u5168\u54e1\u53c2\u52a0\uff09\u30fb\u30bb\u30c3\u30b7\u30e7\u30f3\u306e\u6d3b\u7528\u304c\u3042\u308a\u3001\u307e\u305f\u305d\u306e\u6d3b\u6c17\u306b\u306f\u9023\u65e5PRO CON\uff08\u30c7\u30a3\u30d9\u30fc\u30c8\uff09\u30fb\u30bb\u30c3\u30b7\u30e7\u30f3\u304c\u591a\u6570\u3001\u83ef\u3005\u3057\u304f\u5c55\u958b\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u3082\u8ca2\u732e\u3057\u3066\u3044\u308b\u3068\u304a\u3082\u3044\u307e\u3059\u3002\u65e5\u672c\u306e\u30a2\u30ec\u30eb\u30ae\u30fc\u5b66\u4f1a\u3068\u306f\u30d7\u30ed\u30b0\u30e9\u30e0\u69cb\u6210\u306e\u6839\u672c\u7684\u306a\u76f8\u9055\u304c\u3042\u308a\u3001\u5927\u3044\u306b\u53c2\u8003\u306b\u3059\u3079\u304d\u70b9\u304c\u3042\u308b\u3068\u304a\u3082\u3044\u307e\u3059\u3002<\/span><br \/>\n<span>\u3000\u4eca\u56de\u306e\u30d7\u30ec\u30ca\u30ea\u30fc\u3084\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\u3067\u5927\u304d\u304f\u6ce8\u76ee\u3092\u6d74\u3073\u3066\u3044\u305f\u8a71\u984c\u306b\u306f\u3001\u98df\u7269\u30a2\u30ec\u30eb\u30ae\u30fc\u306b\u304a\u3051\u308b\u201c\u98df\u3079\u3066\u6cbb\u3059\u201d\u7d4c\u53e3\u514d\u75ab\u7642\u6cd5\u306e\u30c8\u30e9\u30a4\u30a2\u30eb\u3001\u30b9\u30c6\u30ed\u30a4\u30c9\u62b5\u6297\u6027\u306e\u91cd\u75c7\u708e\u75c7\u75c5\u614b\u306b\u95a2\u4e0e\u3059\u308bTh17\u8a98\u5c0e\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3001\u5598\u606f\u7b49\u306b\u304a\u3051\u308b\u30ad\u30fc\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3067\u3042\u308bIL-13\u306e\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u3088\u308b\u6301\u7d9a\u7684\u7523\u751f\u3001\u307e\u305f\u7c73\u56fdFDA\u306e\u58f0\u660e\u306b\u7acb\u811a\u3057\u305f\u5598\u606f\u306b\u304a\u3051\u308b\u9577\u6642\u9593\u4f5c\u7528\u578b\u03b2\uff12\u523a\u6fc0\u85ac\u306e\u96e2\u8131(\u30b9\u30c6\u30c3\u30d7\u30c0\u30a6\u30f3)\u306b\u95a2\u308f\u308b\u30e1\u30c3\u30bb\u30fc\u30b8\uff08\u5598\u606f\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u304c\u3064\u3051\u3070\u53ef\u80fd\u306a\u9650\u308a\u96e2\u8131\u3055\u305b\u308b\uff09\u306a\u3069\u304c\u76db\u308a\u8fbc\u307e\u308c\u3066\u3044\u307e\u3057\u305f\u3002<\/span><br \/>\n<span>\u3000\u30d4\u30fc\u30ca\u30c3\u30c4\u306f\u7c73\u56fd\u4eba\u306e1.1\uff05\u304c\u30a2\u30ec\u30eb\u30ae\u30fc\u3092\u793a\u3057\u3001\u7c73\u56fd\u306b\u304a\u3051\u308b\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u3068\u6b7b\u4ea1\u306e\u5927\u304d\u306a\u539f\u56e0\u3067\u3059\u3001\u3053\u306e\u75c5\u614b\u306b\u5bfe\u3057\u3066\u53b3\u91cd\u306a\u7ba1\u7406\u4e0b\u3067\u30d4\u30fc\u30ca\u30c3\u30c4\u6210\u5206\u3092\u5897\u91cf\u3057\u306a\u304c\u3089\u7d4c\u53e3\u6295\u4e0e\u3057\u3001\u514d\u75ab\u5b66\u7684\u5bdb\u5bb9\u3092\u3064\u304f\u308d\u3046\u3068\u3059\u308b\u3044\u308f\u3086\u308b\u7d4c\u53e3\u514d\u75ab\u7642\u6cd5\u306e\u4e8c\u91cd\u76f2\u9a13\u6bd4\u8f03\u8a66\u9a13\u306e\u5831\u544a\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u6210\u529f\u7387\u306f\u305d\u308c\u306a\u308a\u306b\u9ad8\u3044\u3082\u306e\u306e\u3001\u5c0e\u5165\u5f8c\u306b\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u3092\u518d\u5ea6\u8d77\u3053\u3059\u30b1\u30fc\u30b9\u3082\u3042\u308b\u3088\u3046\u3067\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u7d4c\u53e3\u514d\u75ab\u7642\u6cd5\u306f\u3053\u308c\u307e\u3067\u98df\u54c1\u306e\u56de\u907f\u3068\u30a8\u30d4\u30da\u30f3\uff08\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u81ea\u5df1\u6ce8\u5c04\u30b7\u30b9\u30c6\u30e0\uff09\u3057\u304b\u306a\u304b\u3063\u305f\u98df\u7269\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u9577\u671f\u7ba1\u7406\u306b\u3001\u8fd1\u672a\u6765\u7684\u306b\u306f\u5149\u660e\u3092\u3042\u305f\u3048\u3066\u3086\u304f\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/span><br \/>\n<span>\u3000Th17\u7d30\u80de\u306f\u5f53\u30bb\u30f3\u30bf\u30fc\u306e\u7814\u7a76\u30c6\u30fc\u30de\u306e\u3072\u3068\u3064\u3067\u3082\u3042\u308a\u3001\u91cd\u7be4\u3067\u30b9\u30c6\u30ed\u30a4\u30c9\u62b5\u6297\u6027\u306e\u597d\u4e2d\u7403\u6027\u708e\u75c7\u3092\u60f9\u8d77\u3059\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3IL-17\u3092\u7523\u751f\u3059\u308b\u3053\u3068\u3067\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u8a98\u5c0e\u306b\u306fIL-1\u03b2, IL-23, IL-6, TGF-\u03b2\u306a\u3069\u304c\u95a2\u4e0e\u3057\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u75c5\u614b\u304c\u57fa\u790e\u306b\u3042\u308b\u3068\u3053\u308d\u306b\u30a6\u30a4\u30eb\u30b9\u3084\u30af\u30ec\u30d6\u30b7\u30a8\u30e9\u306a\u3069\u306e\u75c5\u539f\u5fae\u751f\u7269\u304c\u4ecb\u5165\u3059\u308b\u3053\u3068\u3067\u3053\u306e\u6d41\u308c\u304c\u751f\u3058\u308b\u7814\u7a76\u6210\u679c\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u307e\u305f\u6025\u6fc0\u306b\u50b7\u3064\u3044\u305f\u7d44\u7e54\uff08\u5916\u50b7\u3084\u3001\u6c17\u9053\u306a\u3089\u523a\u6fc0\u7269\u5438\u5165\u3082\u305d\u3046\u3067\u3057\u3087\u3046\u304b\uff09\u3082Th17\u8a98\u5c0e\u306b\u5fc5\u8981\u306aIL-6\u306e\u7d44\u7e54\u6fc3\u5ea6\u3092\u3042\u3052\u308b\u305d\u3046\u3067\u3001\u3053\u308c\u3082\u307e\u305f\u4f8b\u3048\u3070\u5598\u606f\u306b\u304a\u3051\u308b\u91cd\u7be4\u306a\u5897\u60aa\u306b\u95a2\u4e0e\u3059\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u3053\u3046\u3057\u305f\u514d\u75ab\u5b66\u7684\u30b7\u30b9\u30c6\u30e0\u306b\u62ee\u6297\u3059\u308b\u6cbb\u7642\u306e\u5275\u85ac\u304c\u6709\u76ca\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/span><br \/>\n<span>\u3000IL-13\u306f\u30a2\u30ec\u30eb\u30ae\u30fc\u3067\u91cd\u8981\u306aTh2\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3067\u3001\u91cd\u75c7\u5598\u606f\u3067\u5897\u52a0\u3057\u3066\u3044\u307e\u3059\u3002\u30a6\u30a4\u30eb\u30b9\u306b\u3088\u308b\u6297\u539f\u63d0\u793a\u7d30\u80de\u3078\u306e\u30b7\u30b0\u30ca\u30eb\u304b\u3089natural killer 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