{"id":377,"date":"2019-10-18T11:26:08","date_gmt":"2019-10-18T02:26:08","guid":{"rendered":"https:\/\/saitama-med-allergy.com\/?p=377"},"modified":"2023-03-06T11:28:37","modified_gmt":"2023-03-06T02:28:37","slug":"michael-e-wechsler%e6%95%99%e6%8e%88%e3%82%92%e3%81%8a%e6%8b%9b%e3%81%8d%e3%81%97%e3%81%a6severe-asthma-special-seminar-2019%e3%82%92%e9%96%8b%e5%82%ac%e3%81%84%e3%81%9f%e3%81%97%e3%81%be%e3%81%97","status":"publish","type":"post","link":"https:\/\/saitama-med-allergy.com\/?p=377","title":{"rendered":"Michael E. Wechsler\u6559\u6388\u3092\u304a\u62db\u304d\u3057\u3066Severe asthma special seminar 2019\u3092\u958b\u50ac\u3044\u305f\u3057\u307e\u3057\u305f\u3002"},"content":{"rendered":"

2019\u5e7410\u670818\u65e518\u6642\u3088\u308a\u57fc\u7389\u533b\u79d1\u5927\u5b66\u672c\u9662\u4e38\u6728\u8a18\u5ff5\u9928\u306b\u304a\u3044\u3066\u3001Severe asthma special seminar 2019\u3092\u958b\u50ac\u3044\u305f\u3057\u307e\u3057\u305f\u3002\u30b3\u30ed\u30e9\u30c9\u5927\u5b66\u533b\u5b66\u90e8\u6559\u6388\u3067\u3044\u3089\u3063\u3057\u3083\u308bMichael E. Wechsler\u5148\u751f\u3092\u304a\u62db\u304d\u3057\u3066\u306e\u7279\u5225\u8b1b\u6f14\u4f01\u753b\u3067\u3042\u308a\u307e\u3057\u305f\u3002
\nWechsler\u5148\u751f\u306f\u7279\u306b\u96e3\u6cbb\u6027\u306e\u597d\u9178\u7403\u6027\u591a\u767a\u8840\u7ba1\u708e\u6027\u8089\u82bd\u816b\u75c7\uff08eosinophilic granulomatosis with polyangiitis\uff1aEGPA\uff09\u306b\u5bfe\u3059\u308b\u6297IL-5\u6297\u4f53\u88fd\u5264\u306e\u6709\u52b9\u6027\u3092\u5831\u544a\u3055\u308c\u305f\u3053\u3068\u3067\u3054\u9ad8\u540d\u306a\u5148\u751f\u3067\u3042\u308a\u307e\u3059\u3002\u4eca\u56de\u306f\u56fd\u969b\u88fd\u85ac\u4f01\u696d\u30a2\u30b9\u30c8\u30e9\u30bc\u30cd\u30ab\u4e3b\u50ac\u306e\u7814\u7a76\u4f1a\u306e\u305f\u3081\u306b\u6765\u65e5\u3055\u308c\u3066\u304a\u308a\u3001\u305d\u306e\u53f8\u4f1a\u3092\u6c38\u7530\u30bb\u30f3\u30bf\u30fc\u9577\u304c\u3054\u62c5\u5f53\u3055\u308c\u308b\u3068\u3044\u3046\u3054\u7e01\u3067\u3001\u57fc\u7389\u533b\u5927\u306e\u30ad\u30e3\u30f3\u30d1\u30b9\u306b\u307e\u3067\u304a\u3044\u3067\u304f\u3060\u3055\u308a\u307e\u3057\u305f\u3002<\/p>\n

\"\u5199\u771f1\"\"\u5199\u771f2\"<\/p>\n

\u3000 EGPA\u3068\u306f\u3001\u672c\u90a6\u3067\u306f\u5143\u3005\u30c1\u30e3\u30fc\u30b0\u30fb\u30b9\u30c8\u30e9\u30a6\u30b9\u75c7\u5019\u7fa4\u3068\u3044\u3046\u75c5\u540d\u3067\u8a8d\u77e5\u3055\u308c\u3066\u3044\u305f\u91cd\u75c7\u5598\u606f\u3092\u4f34\u3046\u5168\u8eab\u6027\u8840\u7ba1\u708e\u3092\u672c\u4f53\u3068\u3057\u305f\u96e3\u6cbb\u6027\u75be\u60a3\u3067\u3059\u3002\u305d\u306e\u75c5\u614b\u306b\u306f\u540d\u524d\u306e\u901a\u308a\u597d\u9178\u7403\u306e\u95a2\u4e0e\u304c\u8a8d\u77e5\u3055\u308c\u3066\u304a\u308a\u3001\u597d\u9178\u7403\u306e\u5897\u6b96\u3092\u963b\u3080\u6297IL-5\u6297\u4f53\u88fd\u5264\u306e\u6709\u52b9\u6027\u304c\u63a8\u6e2c\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u30022017\u5e745\u6708\u306b\u540d\u9580\u8a8cNew England Journal of Medicine(NEJM)\u306b\u304a\u3044\u3066\u3001Wechsler\u5148\u751f\u306f\u96e3\u6cbb\u6027EGPA\u60a3\u8005\u306b\u6297Il-5\u6297\u4f53\u88fd\u5264\u3092\u6295\u4e0e\u3057\u3001\u5bdb\u89e3\u7dad\u6301\u671f\u9593\u3084\u5bdb\u89e3\u7dad\u6301\u7387\u304c\u30d7\u30e9\u30bb\u30dc\u7fa4\u306b\u5bfe\u3057\u3066\u6709\u610f\u306b\u6539\u5584\u3055\u308c\u305f\u3053\u3068\u3092\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u305d\u306e\u4ed6\u306b\u3082\u9577\u6642\u9593\u4f5c\u7528\u578b\u03b2\u523a\u6fc0\u85ac\u7642\u6cd5\u306b\u5bfe\u3059\u308b\u03b2\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u53d7\u5bb9\u4f53\u907a\u4f1d\u5b50\u591a\u578b\u306e\u5f71\u97ff\u3084\u3001\u6c17\u7ba1\u652f\u71b1\u5f62\u6210\u8853\u306e\u6709\u52b9\u6027\u306b\u3064\u3044\u3066\u306e\u5317\u7c73\u5927\u898f\u6a21\u81e8\u5e8a\u7814\u7a76\u306e\u304a\u307e\u3068\u3081\u5f79\u3068\u3057\u3066\u6210\u679c\u3092\u5831\u544a\u3055\u308c\u308b\u306a\u3069\u3001\u4eca\u65e5\u306e\u7279\u306b\u91cd\u75c7\u5598\u606f\u306e\u81e8\u5e8a\u7814\u7a76\u306b\u304a\u3051\u308b\u7b2c\u4e00\u4eba\u8005\u306e\u5148\u751f\u3067\u3042\u308a\u307e\u3059\u3002
\n\u4eca\u56de\u306f\u6c17\u7ba1\u652f\u5598\u606f\u306b\u304a\u3051\u308bphenotype\u3068endotype\u306e\u89e3\u8aac\u306b\u59cb\u307e\u308a\u3001\u305d\u306e\u75c5\u578b\u3084\u5404\u7a2e\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3001\u305d\u3057\u3066\u305d\u308c\u3089\u306b\u3088\u308a\u6c17\u9053\u306b\u96c6\u7a4d\u3057\u3066\u6d3b\u6027\u5316\u3059\u308b\u597d\u9178\u7403\u306e\u75c5\u614b\u3078\u306e\u95a2\u4e0e\u7b49\u3092\u5305\u62ec\u7684\u306b\u8b1b\u7fa9\u3057\u3066\u304f\u3060\u3055\u3044\u307e\u3057\u305f\u3002\u672c\u8b1b\u6f14\u3067\u306f\u3001\u547c\u5438\u5668\u5185\u79d1\u6763\u51c6\u6559\u6388\u304cfirst author\u3067\u5831\u544a\u3055\u308c\u305f\u6c17\u7ba1\u652f\u5598\u606f\u306e\u6025\u6027\u5897\u60aa\u30ea\u30b9\u30af\uff08\u672b\u68a2\u8840\u597d\u9178\u7403\u6570\u3001\u3068\u304f\u306b\u597d\u9178\u7403\u6570\u3068\u547c\u6c17NO\u5024\u306e\u4e21\u8005\u304c\u63c3\u3063\u3066\u9ad8\u5024\u3067\u3042\u308b\u3068\u5598\u606f\u306e\u6025\u6027\u5897\u60aa\u30ea\u30b9\u30af\u3068\u306a\u308b\uff09\u306b\u3064\u3044\u3066\u3082\u89e6\u308c\u3089\u308c\u3001\u57fc\u7389\u533b\u5927\u306e\u7814\u7a76\u5831\u544a\u306b\u3064\u3044\u3066Wechsler\u5148\u751f\u3088\u308a\u304a\u8912\u3081\u306e\u8a00\u8449\u3092\u3044\u305f\u3060\u304d\u307e\u3057\u305f\u3002
\n\u307e\u305f\u3054\u8b1b\u6f14\u306e\u5f8c\u534a\u306b\u306f\u3001\u6700\u65b0\u306e\u77e5\u898b\u3092\u4ea4\u3048\u305f\u6297IL-5R\u03b1\u6297\u4f53\u88fd\u5264\u3001\u6297IL-4\/IL-13\u6297\u4f53\u88fd\u5264\u3092\u306f\u3058\u3081\u3068\u3057\u305f\u751f\u7269\u5b66\u7684\u88fd\u5264\u306e\u81e8\u5e8a\u8a66\u9a13\u7d50\u679c\u306b\u3064\u3044\u3066\u3082\u304a\u306f\u306a\u3057\u3092\u3044\u305f\u3060\u304d\u307e\u3057\u305f\u3002\u5f53\u79d1\u3092\u542b\u3081\u5c0f\u5150\u79d1\u3084\u76ae\u819a\u79d1\u306a\u3069\u30a2\u30ec\u30eb\u30ae\u30fc\u75be\u60a3\u8a3a\u7642\u306b\u5f93\u4e8b\u3059\u308b\u8a3a\u7642\u79d1\u533b\u5e2b\u306b\u306f\u3068\u3066\u3082\u826f\u3044\u52c9\u5f37\u3001\u523a\u6fc0\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u30c7\u30a3\u30b9\u30ab\u30c3\u30b7\u30e7\u30f3\u3067\u306f\u5f53\u30bb\u30f3\u30bf\u30fc\u4e3b\u50ac\u52c9\u5f37\u4f1a\u7b49\u306b\u306f\u6e96\u30ec\u30ae\u30e5\u30e9\u30fc\u7684\u306b\u3054\u53c2\u52a0\u304f\u3060\u3055\u308b\u3001\u9632\u885b\u533b\u5927\u547c\u5438\u5668\u5185\u79d1\u306e\u5bae\u7530\u7d14\u5148\u751f\uff08\u61c7\u89aa\u4f1a\u306e\u96c6\u5408\u5199\u771f\u3067\u5de6\u304b\u30892\u756a\u76ee\uff09\u306a\u3069\u304c\u6d3b\u767a\u306a\u3054\u8cea\u554f\u3001\u8a0e\u8ad6\u3092\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002
\n\u7d42\u4e86\u5f8c\u3001\u5b66\u5185\u30ec\u30b9\u30c8\u30e9\u30f3\u300c\u30d5\u30a9\u30f3\u30c6\u30a4\u30cc\u300d\u306b\u304a\u3044\u3066\u61c7\u89aa\u4f1a\u304c\u958b\u304b\u308c\u307e\u3057\u305f\u3002<\/p>\n

\"\u5199\u771f3\"\"\u5199\u771f4\"<\/p>\n

\u3000Wechsler\u5148\u751f\u306f\u3082\u3068\u3082\u3068\u30e2\u30f3\u30c8\u30ea\u30aa\u30fc\u30eb\u306e\u3054\u51fa\u8eab\u3067\u5b66\u751f\u6642\u4ee3\u306f\u30ab\u30ca\u30c0\u306e\u56fd\u6280\u30a2\u30a4\u30b9\u30db\u30c3\u30b1\u30fc\u306e\uff27\uff2b\u3060\u3063\u305f\u305d\u3046\u3067\u3042\u308a\u3001\u672c\u5b66\u30a2\u30a4\u30b9\u30db\u30c3\u30b1\u30fc\u90e8\u306e\u4e3b\u5c06\u3067\u3042\u3063\u305f\u5c0f\u5150\u79d1\u53e4\u8cc0\u533b\u5e2b\uff08\u5199\u771f\u2191\u306e\u30c4\u30fc\u30b7\u30e7\u30c3\u30c8\uff5e\uff01\uff09\u3001\u307e\u305f\u540c\u90e8\u306e\uff27\uff2b\u3067\u3042\u3063\u305f\u6c38\u7530\u30bb\u30f3\u30bf\u30fc\u9577\u306a\u3069\u3068\u3082\u30a2\u30a4\u30b9\u30db\u30c3\u30b1\u30fc\u8ac7\u7fa9\u306b\u3082\u83ef\u304c\u54b2\u3044\u3066\u3044\u307e\u3057\u305f\u3002\u307e\u305f\u57fc\u7389\u533b\u5927\u547c\u5438\u5668\u5185\u79d1\u306e\u3082\u3046\u3072\u3068\u308a\u306e\u6559\u6388\u3067\u3042\u308b\u4ef2\u6751\u79c0\u4fca\u6559\u6388\uff08\u96c6\u5408\u5199\u771f\u5de6\u304b\u30893\u756a\u76ee\uff09\u3068\u306f\u540c\u5148\u751f\u306e\u30dc\u30b9\u30c8\u30f3\u7559\u5b66\u6642\u4ee3\u306b\u3054\u4e00\u7dd2\u3067\u3042\u3089\u308c\u305f\u3053\u3068\u304c\u3042\u308b\u7531\u3067\u3001\u4e45\u95ca\u3092\u53d9\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002
\n\u5f53\u30a2\u30ec\u30eb\u30ae\u30fc\u30bb\u30f3\u30bf\u30fc\u306f\u73fe\u5728\u3001\u65e5\u672c\u30a2\u30ec\u30eb\u30ae\u30fc\u5b66\u4f1a\u306e\u95a2\u6771\u652f\u90e8\u3001\u307e\u305f\u30a2\u30ec\u30eb\u30ae\u30fc\u30fb\u597d\u9178\u7403\u7814\u7a76\u4f1a\u306e\u4e8b\u52d9\u5c40\u306a\u3069\u3092\u9810\u304b\u308b\u3060\u3051\u3067\u306a\u304f\u30012021\u5e74\u306b\u306f\u65e5\u672c\u30a2\u30ec\u30eb\u30ae\u30fc\u5b66\u4f1a\u5b66\u8853\u5927\u4f1a\u3092\u4e3b\u50ac\u3059\u308b\u3053\u3068\u3068\u306a\u3063\u3066\u304a\u308a\u3001\u4eca\u5f8c\u3082\u6211\u304c\u56fd\u306b\u304a\u3051\u308b\u30a2\u30ec\u30eb\u30ae\u30fc\u75be\u60a3\u7814\u7a76\u306e\u62e0\u70b9\u306e\u3072\u3068\u3064\u3068\u3057\u3066\u3001\u4eca\u56de\u306e\u3088\u3046\u306b\u56fd\u969b\u7684\u7814\u7a76\u8005\u3092\u62db\u8acb\u3057\u3066\u306e\u7279\u5225\u8b1b\u6f14\u4f1a\u7b49\u3092\u7d99\u7d9a\u7684\u306b\u958b\u50ac\u3057\u3066\u3044\u3051\u308c\u3070\u3042\u308a\u304c\u305f\u3044\u3082\u306e\u3068\u5b58\u3058\u307e\u3059\u3002\uff08\u6587\u8cac\u3000\u547c\u5438\u5668\u5185\u79d1\u30fb\u7247\u5c71\u548c\u7d00\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"

2019\u5e7410\u670818\u65e518\u6642\u3088\u308a\u57fc\u7389\u533b\u79d1\u5927\u5b66\u672c\u9662\u4e38\u6728\u8a18\u5ff5\u9928\u306b\u304a\u3044\u3066\u3001Severe asthma special seminar 2019\u3092\u958b\u50ac\u3044\u305f\u3057\u307e\u3057\u305f\u3002\u30b3\u30ed\u30e9\u30c9\u5927\u5b66\u533b\u5b66\u90e8\u6559\u6388\u3067\u3044\u3089\u3063\u3057\u3083\u308bMichael E. Wec […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-377","post","type-post","status-publish","format-standard","hentry","category-2"],"_links":{"self":[{"href":"https:\/\/saitama-med-allergy.com\/index.php?rest_route=\/wp\/v2\/posts\/377","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/saitama-med-allergy.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/saitama-med-allergy.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/saitama-med-allergy.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/saitama-med-allergy.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=377"}],"version-history":[{"count":1,"href":"https:\/\/saitama-med-allergy.com\/index.php?rest_route=\/wp\/v2\/posts\/377\/revisions"}],"predecessor-version":[{"id":382,"href":"https:\/\/saitama-med-allergy.com\/index.php?rest_route=\/wp\/v2\/posts\/377\/revisions\/382"}],"wp:attachment":[{"href":"https:\/\/saitama-med-allergy.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=377"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/saitama-med-allergy.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=377"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/saitama-med-allergy.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=377"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}